Association Between Busulfan Exposure and Outcome in Children Receiving Intravenous Busulfan Before Hematopoietic Stem Cell Transplantation

@article{Ansari2014AssociationBB,
  title={Association Between Busulfan Exposure and Outcome in Children Receiving Intravenous Busulfan Before Hematopoietic Stem Cell Transplantation},
  author={M. Ansari and Y. Th{\'e}{\^o}ret and M. A. Rezgui and C. Peters and S. Mezziani and C. Desjean and Marie-France Vachon and M. Champagne and M. Duval and M. Krajinovic and H. Bittencourt},
  journal={Therapeutic Drug Monitoring},
  year={2014},
  volume={36},
  pages={93–99}
}
  • M. Ansari, Y. Théôret, +8 authors H. Bittencourt
  • Published 2014
  • Medicine
  • Therapeutic Drug Monitoring
  • Background and Objective: Intravenous (IV) busulfan (Bu) combined with therapeutic drug monitoring-guided dosing is associated with better event-free survival (EFS), lower transplant-related mortality. But optimal target steady-state concentration (Css) of Bu in children undergoing hematopoietic stem cell transplantation (HSCT) remains unclear. This study aimed to evaluate the relation between Css of Bu and clinical outcomes in children receiving Bu before HSCT. Methods: This study includes 75… CONTINUE READING
    41 Citations

    Paper Mentions

    OBSERVATIONAL CLINICAL TRIAL
    Test the correlations between the pharmacogenetic and pharmacokinetic of Busulfan IV in children receiving hematopoietic stem cell transplantation.  
    ConditionsChildren Who Receive a Stem Cell Transplantation With Busulfan IV
    Single Daily Busulfan Dosing for Infants with Nonmalignant Diseases Undergoing Reduced-Intensity Conditioning for Allogeneic Hematopoietic Progenitor Cell Transplantation.
    • J. Ward, M. Kletzel, +4 authors W. Tse
    • Medicine
    • Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
    • 2015
    • 10
    Busulfan Pharmacokinetics and Precision Dosing: Are Patients with Fanconi Anemia Different?
    • P. Mehta, C. Emoto, +7 authors F. Boulad
    • Medicine
    • Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
    • 2019
    • 2
    GSTA1 Genetic Variants and Conditioning Regimen: Missing Key Factors in Dosing Guidelines of Busulfan in Pediatric Hematopoietic Stem Cell Transplantation.
    • 8
    Performance of Busulfan Dosing Guidelines for Pediatric Hematopoietic Stem Cell Transplant Conditioning.
    • J. Zao, T. Schechter, +5 authors L. Dupuis
    • Medicine
    • Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
    • 2015
    • 27

    References

    SHOWING 1-10 OF 51 REFERENCES
    Association between busulfan exposure and outcome in children receiving intravenous busulfan before hematologic stem cell transplantation.
    • I. Bartelink, R. G. Bredius, +8 authors J. Boelens
    • Medicine
    • Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
    • 2009
    • 87
    Target dose adjustment of busulfan in pediatric patients undergoing bone marrow transplantation
    • 113
    • PDF
    Busulfan concentration and graft rejection in pediatric patients undergoing hematopoietic stem cell transplantation
    • 93
    • Highly Influential
    • PDF
    Pharmacokinetic disposition and clinical outcomes in infants and children receiving intravenous busulfan for allogeneic hematopoietic stem cell transplantation.
    • T. Schechter, Y. Finkelstein, +4 authors L. Dupuis
    • Medicine
    • Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation
    • 2007
    • 49
    Busulfan pharmacokinetics do not predict relapse in acute myeloid leukemia
    • 22
    • PDF