Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults.

@article{Risacher2016AssociationBA,
  title={Association Between Anticholinergic Medication Use and Cognition, Brain Metabolism, and Brain Atrophy in Cognitively Normal Older Adults.},
  author={Shannon L. Risacher and Brenna C. McDonald and Eileen F. Tallman and John D. West and Martin R. Farlow and Fredrick W Unverzagt and Sujuan Gao and Malaz Boustani and Paul K Crane and Ronald C. Petersen and Clifford R. Jack and William J. Jagust and Paul S. Aisen and Michael W Weiner and Andrew J. Saykin},
  journal={JAMA neurology},
  year={2016},
  volume={73 6},
  pages={
          721-32
        }
}
IMPORTANCE The use of anticholinergic (AC) medication is linked to cognitive impairment and an increased risk of dementia. To our knowledge, this is the first study to investigate the association between AC medication use and neuroimaging biomarkers of brain metabolism and atrophy as a proxy for understanding the underlying biology of the clinical effects of AC medications. OBJECTIVE To assess the association between AC medication use and cognition, glucose metabolism, and brain atrophy in… CONTINUE READING
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