Association Analysis of NLRP3 Inflammation-Related Gene Promotor Methylation as Well as Mediating Effects on T2DM and Vascular Complications in a Southern Han Chinese Population

  title={Association Analysis of NLRP3 Inflammation-Related Gene Promotor Methylation as Well as Mediating Effects on T2DM and Vascular Complications in a Southern Han Chinese Population},
  author={Zixing Zhou and Lijun Wang and Zi-hao Wen and Shao-ling Zheng and Xiaohong Ye and Dan-dan Liu and Jing Wu and Xiao-qian Zou and Yu-mei Liu and Yao Wang and Shirui Dong and Xiu Xia Huang and Xiuben Du and Kehui Zhu and Xiaojing Chen and Shiqi Huang and Chengli Zeng and Yajing Han and Bao-huan Zhang and Li-hong Nie and Guang Yang and Chunxia Jing},
  journal={Frontiers in Endocrinology},
Objective: To explore the association between the methylation levels in the promoter regions of the NLRP3, AIM2, and ASC genes and T2DM and its vascular complications in a Southern Han Chinese population and further analyze their interaction and mediating effects with environmental factors in T2DM. Methods: A case-control study was used to determine the association between population characteristics, the methylation level in the promoter region of the NLRP3, AIM2, and ASC genes and T2DM and… Expand
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