Association Analysis of Bone Mineral Density and Single Nucleotide Polymorphisms in Two Candidate Genes on Chromosome 1p36

@article{Spotila2003AssociationAO,
  title={Association Analysis of Bone Mineral Density and Single Nucleotide Polymorphisms in Two Candidate Genes on Chromosome 1p36},
  author={Loretta D Spotila and H{\'e}ctor Xavier Alfaro Rodr{\'i}guez and Marcus A Koch and Harriet S. Tenenhouse and Allen Tenenhouse and Hua-fang Li and Marcella Devoto},
  journal={Calcified Tissue International},
  year={2003},
  volume={73},
  pages={140-146}
}
Two candidate genes for bone mineral density (BMD), tumor necrosis factor alpha receptor 2 (TNFRSF1B) and lysyl hydroxylase (PLOD1), have been scanned for single nucleotide polymorphisms (SNPs) within their coding and promoter regions. These two genes, separated by about 200 kb, are located within the chromosomal interval 1p36.2–1p36.3 that has been linked to femoral neck BMD. In a patient population (n = 104) of European descent, there were four SNPs within TNFRSF1B and six SNPs within PLOD1… CONTINUE READING

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