Association/dissociation of gonadotropin subunits involves disulfide bridge disruption which is influenced by carbohydrate moiety.

@article{Galet2004AssociationdissociationOG,
  title={Association/dissociation of gonadotropin subunits involves disulfide bridge disruption which is influenced by carbohydrate moiety.},
  author={Colette Galet and François Lecompte and Yves Combarnous},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={324 2},
  pages={
          868-73
        }
}
The association and dissociation rates of pituitary porcine luteinizing hormone (pLH) and equine LH (eLH) at oxidizing potential were slow and those of equine choriogonadotropin (eCG) were even much slower. At reducing potential mimicking endoplasmic reticulum condition, association of pLH subunits was observed in less than 5 min instead of 24 h at oxidizing potential. At neutral pH and 37 degrees C, DTNB and 2-nitro-5-thiocyanobenzoic acid (NTCB) were found to react with two cysteine residues… CONTINUE READING
BETA