Assignment1 of the human basic fibroblast growth factor gene FGF2 to chromosome 4 band q26 by radiation hybrid mapping

  title={Assignment1 of the human basic fibroblast growth factor gene FGF2 to chromosome 4 band q26 by radiation hybrid mapping},
  author={H.-S. Kim},
  journal={Cytogenetic and Genome Research},
  pages={73 - 73}
  • H.-S. Kim
  • Published 1 February 1999
  • Biology, Medicine
  • Cytogenetic and Genome Research
Human basic fibroblast growth factor (FGF-2), originally isolated as an angiogenic endothelial cell mitogen for fibroblasts from the kidney, heart, liver, and breast carcinoma, is expressed at low levels in many tissues (Abraham et al., 1986). FGF-2 has been implicated in multiple biological activities including limb development, wound healing, cellular differentiation, tumor growth and angiogenesis. Recently it has been shown to have a specific role in cortical neurogenesis and skin wound… 
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    European review for medical and pharmacological sciences
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It is suggested that MSCs and FGF2 have a synergistic role in the treatment of LPS-induced lung injury.
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MiR-195-5p inhibits tumorigenesis of GC through suppressing bFGF, which supports both miR- 195- 5p and bF GF as potential therapeutic targets in the treatment of GC.
Improved cardiac differentiation of human adipose tissue-derived stem cells using a combination of bFGF and BMP4
It seems that a combination of bFGF and BMP4 improves cardiac differentiation of ADSCs, which is more effective for cardiac differentiation when the induction medium is supplemented with FBS compared with B27.
Effect of recombinant human endostatin on the expression of c-Myc and bFGF in mouse gastric cancer cells.
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Antisense Oligonucleotides Targeting Angiogenic Factors as Potential Cancer Therapeutics
Fibrogenesis and fibrosis in inflammatory bowel diseases: Good and bad side of same coin?
An overview of recent advances in molecular mechanisms of stricturizing Crohn's disease (CD) including the potential role of trasforming growth factor beta, protein kinase C and Ras, Raf and ERK proteins is reported and a possible molecular pattern for mucosal healing is hypothesized.
Mixtures of recombinant growth factors inhibit the production of pro-inflammatory mediators and cytokines in LPS-stimulated RAW 264.7 cells by inactivating the ERK and NF-κB pathways.
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Human basic fibroblast growth factor: nucleotide sequence and genomic organization.
Southern blot analysis of human genomic DNA and mapping of the cloned gene shows that there is only one basic FGF gene, and all of the basic, heparin‐binding endothelial cell mitogens of similar amino acid composition that have been described must be products of this single gene.
Neuronal defects and delayed wound healing in mice lacking fibroblast growth factor 2.
Results indicate that FGF2, although not essential for embryonic development, plays a specific role in cortical neurogenesis and skin wound healing in mice, which, in spite of the apparent redundancy of FGF signaling, cannot be carried out by other FGF family members.
The human basic fibroblast growth factor gene is located on the long arm of chromosome 4 at bands q26-q27.
Using in situ chromosomal hybridization, the gene encoding the basic fibroblast growth factor is mapped to chromosome 4 at bands q26-q27.5, but on a distinct region.
The human basic fibroblast growth factor gene (FGFB) is assigned to chromosome 4q25.
In situ hybridization was used to localize a cDNA probe for the basic fibroblast growth factor gene (FGFB) to human metaphase and prometaphase chromosomes and the localization of this gene to 4q25 is reported.
Molecular features of the TSPY gene of gibbons and Old World monkeys.
  • H. KimH. HiraiO. Takenaka
  • Biology
    Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology
  • 1996
It is speculated that the gibbons might have evolved some structural differentiation in the TSPY gene, as one hundred thirty-seven of 606 sites were found to be variable, and 10 deletions/insertions were noted among these gibbons, two species of Old World monkeys and human.
Assignment 1 of the human basic fibroblast growth factor gene FGF 2 to chromosome 4 band q 26 by radiation hybrid mapping