Assignment1 of the human basic fibroblast growth factor gene FGF2 to chromosome 4 band q26 by radiation hybrid mapping

@article{Kim1998Assignment1OT,
  title={Assignment1 of the human basic fibroblast growth factor gene FGF2 to chromosome 4 band q26 by radiation hybrid mapping},
  author={H.-S. Kim},
  journal={Cytogenetic and Genome Research},
  year={1998},
  volume={83},
  pages={73 - 73}
}
  • H.-S. Kim
  • Published 1 February 1999
  • Biology, Medicine
  • Cytogenetic and Genome Research
Human basic fibroblast growth factor (FGF-2), originally isolated as an angiogenic endothelial cell mitogen for fibroblasts from the kidney, heart, liver, and breast carcinoma, is expressed at low levels in many tissues (Abraham et al., 1986). FGF-2 has been implicated in multiple biological activities including limb development, wound healing, cellular differentiation, tumor growth and angiogenesis. Recently it has been shown to have a specific role in cortical neurogenesis and skin wound… 
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References

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TLDR
Southern blot analysis of human genomic DNA and mapping of the cloned gene shows that there is only one basic FGF gene, and all of the basic, heparin‐binding endothelial cell mitogens of similar amino acid composition that have been described must be products of this single gene.
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Results indicate that FGF2, although not essential for embryonic development, plays a specific role in cortical neurogenesis and skin wound healing in mice, which, in spite of the apparent redundancy of FGF signaling, cannot be carried out by other FGF family members.
The human basic fibroblast growth factor gene is located on the long arm of chromosome 4 at bands q26-q27.
TLDR
Using in situ chromosomal hybridization, the gene encoding the basic fibroblast growth factor is mapped to chromosome 4 at bands q26-q27.5, but on a distinct region.
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TLDR
It is speculated that the gibbons might have evolved some structural differentiation in the TSPY gene, as one hundred thirty-seven of 606 sites were found to be variable, and 10 deletions/insertions were noted among these gibbons, two species of Old World monkeys and human.
Assignment 1 of the human basic fibroblast growth factor gene FGF 2 to chromosome 4 band q 26 by radiation hybrid mapping