Assignment1 of the human basic fibroblast growth factor gene FGF2 to chromosome 4 band q26 by radiation hybrid mapping

@article{Kim1998Assignment1OT,
  title={Assignment1 of the human basic fibroblast growth factor gene FGF2 to chromosome 4 band q26 by radiation hybrid mapping},
  author={H.-S. Kim},
  journal={Cytogenetic and Genome Research},
  year={1998},
  volume={83},
  pages={73 - 73}
}
  • H.-S. Kim
  • Published 1 February 1999
  • Biology, Medicine
  • Cytogenetic and Genome Research
Human basic fibroblast growth factor (FGF-2), originally isolated as an angiogenic endothelial cell mitogen for fibroblasts from the kidney, heart, liver, and breast carcinoma, is expressed at low levels in many tissues (Abraham et al., 1986). FGF-2 has been implicated in multiple biological activities including limb development, wound healing, cellular differentiation, tumor growth and angiogenesis. Recently it has been shown to have a specific role in cortical neurogenesis and skin wound… 
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19 Citations
Background Citations
7
Methods Citations
1

19 Citations

Adenovirus-mediated transfer of siRNA against basic fibroblast growth factor mRNA enhances the sensitivity of glioblastoma cells to chemotherapy
TLDR
Targeting bFGF mRNA with a siRNA resulted in lower rates of proliferation, increased apoptosis, and enhanced sensitivity of glioma cells to chemotherapy drugs, suggesting that specific targeting of bF GF mRNA may provide a novel approach for the treatment ofglioblastoma multiforme (GBM).
Mesenchymal stem cell-based FGF2 gene therapy for acute lung injury induced by lipopolysaccharide in mice.
  • Y-F ZhaoY. Luo X-L Wu
  • Biology, Medicine
    European review for medical and pharmacological sciences
  • 2015
TLDR
It is suggested that MSCs and FGF2 have a synergistic role in the treatment of LPS-induced lung injury.
MicroRNA-195 inhibits human gastric cancer by directly targeting basic fibroblast growth factor
TLDR
MiR-195-5p inhibits tumorigenesis of GC through suppressing bFGF, which supports both miR- 195- 5p and bF GF as potential therapeutic targets in the treatment of GC.
Shallow whole genome sequencing of adenoid cystic carcinomas of the salivary glands identifies specific chromosomal aberrations related to tumor progression.
Improved cardiac differentiation of human adipose tissue-derived stem cells using a combination of bFGF and BMP4
TLDR
It seems that a combination of bFGF and BMP4 improves cardiac differentiation of ADSCs, which is more effective for cardiac differentiation when the induction medium is supplemented with FBS compared with B27.
Effect of recombinant human endostatin on the expression of c-Myc and bFGF in mouse gastric cancer cells.
TLDR
It is demonstrated that recombinant human endostatin could in-hibit tumor metastasis by inhibition of the expression of c-Myc and bFGF in gastric cancer tissue as well asBy inhibition of angiogenesis.
Antisense Oligonucleotides Targeting Angiogenic Factors as Potential Cancer Therapeutics
Correlations of EGF G1380A, bFGF C754G and VEGF T460C polymorphisms with malignant melanoma susceptibility and prognosis: A case-control study.
Fibrogenesis and fibrosis in inflammatory bowel diseases: Good and bad side of same coin?
TLDR
An overview of recent advances in molecular mechanisms of stricturizing Crohn's disease (CD) including the potential role of trasforming growth factor beta, protein kinase C and Ras, Raf and ERK proteins is reported and a possible molecular pattern for mucosal healing is hypothesized.
Mixtures of recombinant growth factors inhibit the production of pro-inflammatory mediators and cytokines in LPS-stimulated RAW 264.7 cells by inactivating the ERK and NF-κB pathways.
TLDR
The results suggest that MRGFs inhibit the production of pro-inflammatory cytokines and NO by downregulating inducible NO synthase gene expression and blocking the phosphorylation of the ERK and NF-κB signaling pathways.
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References

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TLDR
Southern blot analysis of human genomic DNA and mapping of the cloned gene shows that there is only one basic FGF gene, and all of the basic, heparin‐binding endothelial cell mitogens of similar amino acid composition that have been described must be products of this single gene.
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TLDR
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TLDR
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TLDR
It is speculated that the gibbons might have evolved some structural differentiation in the TSPY gene, as one hundred thirty-seven of 606 sites were found to be variable, and 10 deletions/insertions were noted among these gibbons, two species of Old World monkeys and human.
Assignment 1 of the human basic fibroblast growth factor gene FGF 2 to chromosome 4 band q 26 by radiation hybrid mapping