Assignment1 of the gene GRM1 coding for metabotropic glutamate receptor 1 to human chromosome band 6q24 by in situ hybridization
@article{Ganesh2000Assignment1OT, title={Assignment1 of the gene GRM1 coding for metabotropic glutamate receptor 1 to human chromosome band 6q24 by in situ hybridization}, author={Subramaniam Ganesh and Kenji Amano and Kazuhiro Yamakawa}, journal={Cytogenetic and Genome Research}, year={2000}, volume={88}, pages={314 - 315} }
Metabotropic glutamate receptors (mGluRs) are important modulators of synaptic transmission and have been implicated in epilepsy, neurotoxicity and neurodegenerative disorders (Schoepp and Conn, 1993). Based on amino acid sequence similarity and agonist selectivity, mGluRs are divided into three groups (Pin and Duvoisin, 1995). Subtype mGluR1 classified as group I has been shown to stimulate the phosphoinositide hydrolysis pathway (Schoepp and Conn, 1993). Mice lacking the mGluR1 gene develop…
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Metabotropic Glutamate 1 Receptor: Current Concepts and Perspectives
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Recent advancements in the pharmacology and concepts about the intracellular transduction and pathophysiological role of mGlu1 receptors are discussed and earlier data is reviewed in view of these novel findings.
Metabotropic glutamate receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
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Although well characterized in transfected cells, co-localization and specific pharmacological properties also suggest the existence of such heterodimers in the brain, without significantly activating the receptor in the absence of agonist.
Mutation screening for Japanese Lafora's disease patients: identification of novel sequence variants in the coding and upstream regulatory regions of EPM2A gene.
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The progressive myoclonus epilepsy of Lafora type (LD) is an autosomal recessive disorder caused by mutations in the EPM2A gene. We demonstrated recently that EPM2A encodes a dual-specificity…
Glutamate receptor genes
- Psychology, MedicineMolecular Neurobiology
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It is likely that mutations in glutamate receptor genes might alter the risk of developing one of these disorders and potential future research directions designed to identify these mutations and to elucidate their effect on mental health will be discussed.
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