Assignment1 of the gene GRM1 coding for metabotropic glutamate receptor 1 to human chromosome band 6q24 by in situ hybridization

  title={Assignment1 of the gene GRM1 coding for metabotropic glutamate receptor 1 to human chromosome band 6q24 by in situ hybridization},
  author={Subramaniam Ganesh and Kenji Amano and Kazuhiro Yamakawa},
  journal={Cytogenetic and Genome Research},
  pages={314 - 315}
Metabotropic glutamate receptors (mGluRs) are important modulators of synaptic transmission and have been implicated in epilepsy, neurotoxicity and neurodegenerative disorders (Schoepp and Conn, 1993). Based on amino acid sequence similarity and agonist selectivity, mGluRs are divided into three groups (Pin and Duvoisin, 1995). Subtype mGluR1 classified as group I has been shown to stimulate the phosphoinositide hydrolysis pathway (Schoepp and Conn, 1993). Mice lacking the mGluR1 gene develop… 

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