Assignment1 of pancreatic eIF-2α kinase (EIF2AK3) to human chromosome band 2p12 by radiation hybrid mapping and in situ hybridization

  title={Assignment1 of pancreatic eIF-2$\alpha$ kinase (EIF2AK3) to human chromosome band 2p12 by radiation hybrid mapping and in situ hybridization},
  author={S. E. Hayes and L. J. Conner and Lawrence E. Stramm and Y. Shi},
  journal={Cytogenetic and Genome Research},
  pages={327 - 328}
Pancreatic eIF-2· kinase (EIF2AK3 alias PEK) is a new member of a family of eIF-2· kinases, which include hemeregulated inhibitor kinase (HRI), the double stranded RNA dependent protein kinase (PKR), and the yeast GCN2 (Shi et al., 1998). EIF2AK3 activity has also been linked to responsiveness to endoplasmic reticulum stress (Harding et al., 1999). Overexpression of one member of the eIF-2· kinase family has been implicated in apoptosis while overexpression of a dominant negative form of the… 

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  • H. HengJ. SquireL. Tsui
  • Biology, Chemistry
    Proceedings of the National Academy of Sciences of the United States of America
  • 1992
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