Assignment1 of human desert hedgehog gene (DHH) to chromosome band 12q13.1 by in situ hybridization

  title={Assignment1 of human desert hedgehog gene (DHH) to chromosome band 12q13.1 by in situ hybridization},
  author={Mitsuhiro Kamisago and Misa Kimura and Yoshiyuki Furutani and Michiko Furutani and Atsuyoshi Takao and Kazuo Momma and Rumiko Matsuoka},
  journal={Cytogenetic and Genome Research},
  pages={117 - 118}
The hedgehog (hh) gene family encodes signaling molecules that play an important role in regulating morphogenesis. There are three known mammalian homologues of hh (Echelard et al., 1993). Of these, the mouse desert hedgehog gene (Dhh) was mapped to the most distal region of mouse chromosome 15 by interspecific backcross analysis (Marigo et al., 1995). Since a region of mouse chromosome 15 is homologous with human chromosome 12, we thought it likely that the human homologue of Dhh would reside… Expand
Desert hedgehog is a mammal-specific gene expressed during testicular and ovarian development in a marsupial
Examination of the expression and protein distribution of DHH, PTCH1 and PTCH2 in the developing testes of a marsupial mammal (the tammar wallaby) suggests that there is a highly conserved role for DHH signalling in the differentiation and function of the mammalian testis and that DHH may be necessary for mars upial ovarian development. Expand
Molecular characterization and expression analysis of Patched 1 gene in the half-smooth tongue sole (Cynoglossus semilaevis)
Results indicate that CsPtc1 may be involved in Desert Hedgehog (DHH) maintenance of the male and pseudo-male germ line and spermatogenesis, with expression level in testis significantly higher than in ovary. Expand
Desert and Sonic Hedgehog Signalling in T cell Differentiation
The data from thymic organ cultures have shown that Shh influences T cell selection and maturation during the later stages of T cell development in their transition from DP to SP cell population. Expand
Generation of an integrated karyotype of the honey bee (Apis mellifera L.) by banding pattern and fluorescent in situ hybridization
The cytogenetic maps of the honey bee karyotype represented in the ideograms were subsequently used to place 35 mapped BACs (Solignac et al. 2004) of Solignac’s BAC library. Expand
Cyclopamine: from cyclops lambs to cancer treatment.
In the late 1960s, the steroidal alkaloid cyclopamine was isolated from the plant Veratrum californicum and identified as the teratogen responsible for craniofacial birth defects including cyclops inExpand


Cloning, expression, and chromosomal location of SHH and IHH: two human homologues of the Drosophila segment polarity gene hedgehog.
The hedgehog genes encode signaling molecules that play a role in regulating embryonic morphogenesis and have cloned and sequenced human cDNA copies of two of these genes, SHH and IHH, which are expressed in adult kidney and liver. Expand
Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity
Three members of a mouse gene family related to the Drosophila segment polarity gene, hedgehog (hh), are identified and it is suggested that Shh may play a role in the normal inductive interactions that pattern the ventral CNS. Expand
Regional location of a novel yes-related proto-oncogene, syn, on human chromosome 6 at band q21.
The present regional mapping substantiated the previous assignment that was performed by analyses of human-mouse somatic cell hybrids and filter blot hybridization and confirmed the novel v-yes-related proto-oncogene assigned to region q21 of human chromosome 6. Expand