Assignment1 of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3→q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping

@article{Grosios1999Assignment1OA,
  title={Assignment1 of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3→q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping},
  author={Konstantina Grosios and Jack P. Leek and A. F. Markham and George D. Yancopoulos and P.F. Jones},
  journal={Cytogenetic and Genome Research},
  year={1999},
  volume={84},
  pages={118 - 120}
}
The recently discovered Angiopoietin family is comprised of four growth factors thought to be very important for vascular development (Davis et al., 1996; Suri et al., 1996; Maisonpierre et al., 1997; Suri et al., 1998; Valenzuela et al., 1999). All four angiopoietins bind to the endothelial cell-specific receptor Tie2 with similar affinity. The mechanism by which these proteins contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting… 

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References

SHOWING 1-9 OF 9 REFERENCES
Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis.
TLDR
The discovery of a negative regulator acting on Tie2 emphasizes the need for exquisite regulation of this angiogenic receptor system.
Increased vascularization in mice overexpressing angiopoietin-1.
TLDR
It is shown that transgenic overexpression of angiopoietin-1 in the skin of mice produces larger, more numerous, and more highly branched vessels, raising the possibility that angioietins can be used, alone or in combination with VEGF to promote therapeutic angiogenesis.
Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization.
TLDR
The use of fluorescence in situ hybridization for chromosome classification and detection of chromosome aberrations is described and chromosomes in human-hamster hybrid cell lines were intensely and uniformly stained in metaphase spreads and interphase nuclei when human genomic DNA was used as a probe.
A method for constructing radiation hybrid maps of whole genomes
TLDR
It is suggested that the construction of a high resolution map of the whole human genome is feasible with a single panel of 100–200 hybrids, using irradiated human fibroblasts as donors.
Angiopoietin 3 and 4: Diverging gene counterparts in mouse and man
  • Proc natl Acad Sci, USA (in press,
  • 1999
Yancopoulos GD: Increased vascularisation in mice overexpressing angiopoietin-1
  • Science
  • 1998