Assignment1 of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3→q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping

  title={Assignment1 of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3→q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping},
  author={Konstantina Grosios and Jack P. Leek and A. F. Markham and George D. Yancopoulos and P.F. Jones},
  journal={Cytogenetic and Genome Research},
  pages={118 - 120}
The recently discovered Angiopoietin family is comprised of four growth factors thought to be very important for vascular development (Davis et al., 1996; Suri et al., 1996; Maisonpierre et al., 1997; Suri et al., 1998; Valenzuela et al., 1999). All four angiopoietins bind to the endothelial cell-specific receptor Tie2 with similar affinity. The mechanism by which these proteins contribute to angiogenesis is thought to involve regulation of endothelial cell interactions with supporting… 

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