Assignment of the human lens fiber cell MP19 gene (LIM2) to chromosome 19q13.4, and adjacent to ETFB

  title={Assignment of the human lens fiber cell MP19 gene (LIM2) to chromosome 19q13.4, and adjacent to ETFB},
  author={K. Lieuallen and M. Christensen and B. Brandriff and R. Church and J. Wang and G. Lennon},
  journal={Somatic Cell and Molecular Genetics},
The LIM2 gene may play a major role in lens fiber cell structure or communication, and thus cataractogenesis. A human cDNA encoding the corresponding lens fiber cell intrinsic protein MP19 has been previously isolated and characterized. This cDNA had been mapped to human chromosome 19. We have independently confirmed this assignment and fine mapped it to 19q13.4. The position of the LIM2 gene appears to be within 40 kb of the electron transport flavoprotein gene (ETFB) as a cosmid containing… Expand
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The basic principles of gene mapping and their application to ophthalmology are presented and the techniques used to map the genome are reviewed with emphasis placed on molecular genetics. Expand
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