Assignment of the gene for dyskeratosis congenita to Xq28

  title={Assignment of the gene for dyskeratosis congenita to Xq28},
  author={J. Michael Connor and Derek Gatherer and Frederick Gray and Lindsay A. Pirrit and N. A. Affara},
  journal={Human Genetics},
Dyskeratosis congenita is an X-linked recessive disorder with diagnostic dermatological features, bone marrow hypofunction, and a predisposition to neoplasia in early adult life. Linkage analysis was undertaken in an extensive family with the condition using the Xg blood group and 17 cloned X chromosomal DNA sequences which recognise restriction fragment length polymorphisms (RFLPs). No recombination was observed between the locus for dyskeratosis congenita (DKC) and the RFLPs identified by… CONTINUE READING
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