Assignment of the NTRK4 (trkE) gene to chromosome 6p21

  title={Assignment of the NTRK4 (trkE) gene to chromosome 6p21},
  author={Alexander Valent and Mounira Meddeb and Gis{\'e}le Danglot and Alexandra Duverger and Van Cong Nguyen and Alain Bernheim},
  journal={Human Genetics},
Abstract Reverse transcriptase-polymerase chain reactions using foetal brain RNA with reverse and forward primers of the first, second and third NTRK4 region allowed us to obtain three amplified NTRK4 fragments. The specificity of amplified fragments was checked by digestion with restriction endonucleases AvrII, HindIII and PspII for the first, second and third regions, respectively. Each restriction site was specific for each amplified fragment. The fragment of the NTRK4 first region was also… 
Mapping of the Tyrosine Kinase Receptors trKA(NTRK1), trkB (NTRK2) and trkC(NTRK3) to Human Chromosomes 1q22, 9q22 and 15q25 by Fluorescence in situ Hybridization
Abstracttrk (NTRK) genes encode tyrosine kinase transmembrane receptors that are stimulated by neurotrophins, and are responsible for the transduction of signals controlling neuropoiesis and neuron
Expression of DDR1 in the CNS and in myelinating oligodendrocytes.
Investigating the structural domains required for activation of the human discoidin domain receptors, DDR1 and DDR2
It is shown that full-length DDRs, expressed on the cell surface, exist as preformed oligomers in the absence of ligand and more than one receptor domain is involved in receptor dimerisation, as the deletion of any one of the above mentioned receptor domains was not sufficient to abolish oligomerisation.
Overexpression of discoidin domain receptor 1 increases the migration and invasion of hepatocellular carcinoma cells in association with matrix metalloproteinase.
This study provided one possible mechanism for the invasion of HCC cells and suggested that the increased invasiveness of the HCC may be associated with the overexpression of either DDR1a or DDR1b mediated by MMP-2 and -9.
Purification of a Novel Flavoprotein Involved in the Thyroid NADPH Oxidase
Microsequences permitted the cloning of porcine and human full-length cDNAs encoding, respectively, 1207- and 1210-amino acid proteins with a predicted molecular mass of 138 kDa (p138Tox), which purified from pig thyroid plasma membrane a flavoprotein which constitutes the main, if not the sole, component of the thyroid NAD(P)H oxidase.
Discoidin domain receptors: structural relations and functional implications
  • W. Vogel
  • Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1999
DDRs display several potential tyrosine phosphorylation sites that are able to relay the signal by interacting with cytoplasmic effector proteins, and the potential cross‐talk to other receptors for collagen and the clinical aspects of DDR function are discussed.
Discoidin domain receptors and their ligand, collagen, are temporally regulated in fetal rat fibroblasts in vitro.
Examining the endogenous expression of DDR1, DDR2, collagen I, and total collagen, as a function of fetal Sprague-Dawley rat skin fibroblasts revealed a pattern of increasing collagen production with increasing gestational ages, whereas DDR1 expression decreased with increasing Gestational age, suggesting that elevated levels of DDR 1 may play an important role in scarless tissue regeneration by early gestation fetal fibro Blasts.
Identification of Synergistic Drug Combinations to Target KRAS-Driven Chemoradioresistant Cancers Utilizing Tumoroid Models of Colorectal Adenocarcinoma and Recurrent Glioblastoma
Treatment resistance is observed in all advanced cancers. Colorectal cancer (CRC) presenting as colorectal adenocarcinoma (COAD) is the second leading cause of cancer deaths worldwide. Multimodality


Molecular cloning of the cDNA for human TrkC (NTRK3), chromosomal assignment, and evidence for a splice variant.
The human trkC cDNA is cloned and sequenced and it is found that the predicted amino acid sequence is 97 to 98% homologous to the rat and porcinetrkC sequences, respectively.
Molecular and biochemical characterization of the human trk proto-oncogene
Results indicate that the product of the human trk locus is a novel tyrosine kinase cell surface receptor for an as yet unknown ligand.
Construction of T-vectors, a rapid and general system for direct cloning of unmodified PCR products.
Cl cloning of polymerase chain reaction products as blunt-ended fragments requires enzymatic processing to remove of the 3' overhang using an enzyme with 3' to 5' exonuclease activity.
Human TRK proto-oncogene maps to chromosome 1q32-q41.
The chromosomal localization of TRK, a gene coding for a putative receptor molecule with an associated tyrosine kinase activity that we have found activated in 25% of patients with papillary thyroid
A new hybrid cell line containing only human chromosome 15 selected through fluorescence in situ hybridization and characterized by Alu-PCR amplification of the human DNA.
Under the applied conditions, the Alu (A33) products are expected to be useful for characterization, by specific decoration of chromosome 15 aberrations in pathological cells by in situ hybridization (FISH).
Localization of the TRK proto-oncogene to human chromosome bands 1q23-1q24.
A FER-related sequence isolated from a human genomic library was found to be homologous to TRK, and in situ hybridization of a 0.92 kb probe localized the TRK gene to the long arm of chromosome 1 within bands 1q23-1q24.
A simple method for simultaneous R- or G-banding and fluorescence in situ hybridization of small single-copy genes.
Results of hybridization of small cDNA probes for the human genes for motilin, thymidylate synthetase, and lymphocyte activation-3 are provided as examples of the high-resolution mapping obtainable with this technique.
trkB, a novel tyrosine protein kinase receptor expressed during mouse neural development.
In situ hybridization analysis of 14 and 18 day old mouse embryos indicates thattrkB transcripts are localized in the central (CNS) and peripheral (PNS) nervous systems, including brain, spinal cord, spinal and cranial ganglia, paravertebral trunk of the sympathetic nervous system and various innervation pathways, suggesting that trkB may code for a novel cell surface receptor involved in neurogenesis.