Assignment of pterin deaminase activity to an enzyme of unknown function guided by homology modeling and docking.

@article{Fan2013AssignmentOP,
  title={Assignment of pterin deaminase activity to an enzyme of unknown function guided by homology modeling and docking.},
  author={Hao Fan and Daniel Stephen Hitchcock and Ronald D. Seidel and Brandan S. Hillerich and Henry K. Lin and Steven C. Almo and Andrej Sali and Brian K. Shoichet and Frank M Raushel},
  journal={Journal of the American Chemical Society},
  year={2013},
  volume={135 2},
  pages={
          795-803
        }
}
Of the over 22 million protein sequences in the nonredundant TrEMBL database, fewer than 1% have experimentally confirmed functions. Structure-based methods have been used to predict enzyme activities from experimentally determined structures; however, for the vast majority of proteins, no such structures are available. Here, homology models of a functionally uncharacterized amidohydrolase from Agrobacterium radiobacter K84 (Arad3529) were computed on the basis of a remote template structure… CONTINUE READING
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