Assignment of protein function and discovery of novel nucleolar proteins based on automatic analysis of MEDLINE.

@article{Schuemie2007AssignmentOP,
  title={Assignment of protein function and discovery of novel nucleolar proteins based on automatic analysis of MEDLINE.},
  author={Martijn J. Schuemie and Christine Loraine Chichester and Fr{\'e}d{\'e}rique Lisacek and Yohann Cout{\'e} and Peter-Jan Roes and Jean Charles S{\'a}nchez and Jan A. Kors and Barend Mons},
  journal={Proteomics},
  year={2007},
  volume={7 6},
  pages={
          921-31
        }
}
Attribution of the most probable functions to proteins identified by proteomics is a significant challenge that requires extensive literature analysis. We have developed a system for automated prediction of implicit and explicit biologically meaningful functions for a proteomics study of the nucleolus. This approach uses a set of vocabulary terms to map and integrate the information from the entire MEDLINE database. Based on a combination of cross-species sequence homology searches and the… CONTINUE READING
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