Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8

@article{Yamada1993AssignmentOH,
  title={Assignment of human thyrotropin-releasing hormone (TRH) receptor gene to chromosome 8},
  author={Michiharu Yamada and T. Monden and Shigeo Konaka and Masatomo Mori},
  journal={Somatic Cell and Molecular Genetics},
  year={1993},
  volume={19},
  pages={577-580}
}
The human gene encoding thyrotropin-releasing hormone receptor was assigned to chromosome 8, using human-Chinese hamster ovary somatic cell hybrids, analyzed by Southern hybridizations. Hybridization was carried out with a32P-labeled fragment of the human TRH-R genomic DNA. Hybridization of this probe to a human specific 10.5-kb DNA fragment of EcoRI-digested WBC DNA was used to localize the human TRH-R gene. No hybridization, by contrast, was seen with this probe and hamster DNA after EcoRI… Expand
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The sequence and functioning analyses showed the same expression of TRH-R mRNA in the pituitary adenomas of patients with acromegaly as that in the normal pituitaries, indicating that 2) the paradoxical response of GH secretion to TRH found in the patients might be a direct effect ofTRH on TRH -R expressed in the adenoma. Expand
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SECTION IV. EFFECTS OF TRH ON SECONDARY MESSENGER SYSTEMS: Mechanism of Signal Transduction by TRH a
The mechanism of action of TRH has been studied intensively during the last several years.’ Pituitary cells have been chosen as the experimental system for the majority of these studies because TRHExpand
Mechanism of signal transduction by TRH.