Assignment of complement components C4 binding protein (C4BP) and factor H (FH) to human chromosome 1q, using cDNA probes

@article{Hing1988AssignmentOC,
  title={Assignment of complement components C4 binding protein (C4BP) and factor H (FH) to human chromosome 1q, using cDNA probes},
  author={S Hing and Anthony J. Day and Sophia Linton and Jean Ripoche and Robert B Sim and Kenneth B. M. Reid and E. Solomon},
  journal={Annals of Human Genetics},
  year={1988},
  volume={52}
}
Using cDNA probes for Factor H (FH) and C4 binding protein (C4BP) on a panel of somatic cell hybrids, we show that both of these genes map to the long arm of chromosome 1. 
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The evidence for a new multi-gene family with a common ancestral protein is discussed and structural, functional and genetic studies of five glycoproteins with both complement regulatory activity and binding affinity for C3b/C4b have been characterized. Expand
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The genes encoding the proteins that constitute the C3-activating enzymes have been cloned and mapped to a "complement activation" locus in the major histocompatibility complex, and it is demonstrated in this study such a locus on the long arm of chromosome 1 at band 1q32. Expand
Human genes for three complement components that regulate the activation of C3 are tightly linked
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Family segregation data indicate that FH is linked to the genes for C4-bp and C4bR, previously reported to be linked and to maintain linkage disequilibrium, and suggest that the organization of genes for functionally related proteins in clusters may be a rule for the complement system. Expand
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