Assignment of 2′-O-Methyltransferases to Modification Sites on the Mammalian Mitochondrial Large Subunit 16 S Ribosomal RNA (rRNA)*

@article{Lee2014AssignmentO2,
  title={Assignment of 2′-O-Methyltransferases to Modification Sites on the Mammalian Mitochondrial Large Subunit 16 S Ribosomal RNA (rRNA)*},
  author={Ken-Wing Lee and Daniel F. Bogenhagen},
  journal={The Journal of Biological Chemistry},
  year={2014},
  volume={289},
  pages={24936 - 24942}
}
Background: rRNA methylation is required for ribosome assembly and/or function. Results: Knockdown of MRM1, MRM2, and RNMTL1 increases susceptibility of mitochondrial 16 S rRNA to site-specific cleavage by DNAzymes. Conclusion: The enzymes responsible for all known 2′-O-ribose methylations of 16 S rRNA are now identified. Significance: Assignment of rRNA modifications to nucleoid-associated proteins implies that mitochondrial ribosome biogenesis begins at the nucleoid. Advances in proteomics… Expand
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