Assigning significance to peptides identified by tandem mass spectrometry using decoy databases.

@article{Kll2008AssigningST,
  title={Assigning significance to peptides identified by tandem mass spectrometry using decoy databases.},
  author={Lukas K{\"a}ll and John D. Storey and Michael J. MacCoss and William Stafford Noble},
  journal={Journal of proteome research},
  year={2008},
  volume={7 1},
  pages={29-34}
}
Automated methods for assigning peptides to observed tandem mass spectra typically return a list of peptide-spectrum matches, ranked according to an arbitrary score. In this article, we describe methods for converting these arbitrary scores into more useful statistical significance measures. These methods employ a decoy sequence database as a model of the null hypothesis, and use false discovery rate (FDR) analysis to correct for multiple testing. We first describe a simple FDR inference method… CONTINUE READING
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