Assessment of whole genome amplification-induced bias through high-throughput, massively parallel whole genome sequencing

@article{Pinard2006AssessmentOW,
  title={Assessment of whole genome amplification-induced bias through high-throughput, massively parallel whole genome sequencing},
  author={Robert Pinard and Alex de Winter and Gary J. Sarkis and Mark B Gerstein and Karrie R. Tartaro and Ramona N Plant and Michael Egholm and Jonathan M. Rothberg and John Harris Leamon},
  journal={BMC Genomics},
  year={2006},
  volume={7},
  pages={216 - 216}
}
Whole genome amplification is an increasingly common technique through which minute amounts of DNA can be multiplied to generate quantities suitable for genetic testing and analysis. Questions of amplification-induced error and template bias generated by these methods have previously been addressed through either small scale (SNPs) or large scale (CGH array, FISH) methodologies. Here we utilized whole genome sequencing to assess amplification-induced bias in both coding and non-coding regions… CONTINUE READING

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