Assessment of vitamin D nutritional and hormonal status: What to measure and how to do it

@article{Hollis2006AssessmentOV,
  title={Assessment of vitamin D nutritional and hormonal status: What to measure and how to do it},
  author={B. W. Hollis},
  journal={Calcified Tissue International},
  year={2006},
  volume={58},
  pages={4-5}
}
  • B. Hollis
  • Published 2006
  • Medicine
  • Calcified Tissue International
The metabolism and mechanism of action of vitamin D has been studied and elucidated quite extensively during the past 25 years. During this period, many metabolites of vitamin D have been identified and many of them subsequently quantitated in the circulation. With all of this information available, what is the physician to do when faced with the problem of which vitamin D metabolite to assess in the circulation in a given clinical circumstance? First, there are four quantitatively significant… 
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  • B. Hollis
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  • 2005
TLDR
It has been more than 3 decades since the first assay assessing circulating 25-hydroxyvitamin D in human subjects was performed and led to the definition of "normal" nutritional vitamin D status, i.e., vitamin D sufficiency, and current dietary recommendations for adults are not sufficient to maintain circulating 25(OH)D levels at or above this level, especially in pregnancy and lactation.
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References

Determination of vitamin D status by radioimmunoassay with an 125I-labeled tracer.
TLDR
The first radioimmunoassay for a vitamin D metabolite utilizing a radioiodinated tracer is reported, comparing well with those from a liquid-chromatographic procedure involving specific ultraviolet detection of 25-hydroxycalciferol in plasma.