Assessment of unstable atherosclerosis in mice.

  title={Assessment of unstable atherosclerosis in mice.},
  author={Christopher Langdale Jackson and Martin R. Bennett and Erik Anna Leonardus Biessen and Jason L Johnson and Rob Krams},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  volume={27 4},
There is an urgent need for representative animal models where prospective examination of the events leading up to plaque rupture and the rupture process itself can be performed. Recently, reports have begun to emerge that apolipoprotein E and low density lipoprotein receptor knockout mice may spontaneously develop unstable atherosclerosis, with plaques in certain parts of the arterial tree showing features suggestive of plaque rupture. Here we discuss the problems inherent in applying… CONTINUE READING
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