Assessment of the upper motor neuron in amyotrophic lateral sclerosis

@article{Huynh2016AssessmentOT,
  title={Assessment of the upper motor neuron in amyotrophic lateral sclerosis},
  author={William Huynh and Neil G Simon and Julian Grosskreutz and Martin R. Turner and Steve Vucic and Matthew C. Kiernan},
  journal={Clinical Neurophysiology},
  year={2016},
  volume={127},
  pages={2643-2660}
}
Clinical signs of upper motor neuron (UMN) involvement are an important component in supporting the diagnosis of amyotrophic lateral sclerosis (ALS), but are often not easily appreciated in a limb that is concurrently affected by muscle wasting and lower motor neuron degeneration, particularly in the early symptomatic stages of ALS. Whilst recent criteria have been proposed to facilitate improved detection of lower motor neuron impairment through electrophysiological features that have improved… 
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