Assessment of the upper motor neuron in amyotrophic lateral sclerosis

@article{Huynh2016AssessmentOT,
  title={Assessment of the upper motor neuron in amyotrophic lateral sclerosis},
  author={W. Huynh and N. Simon and J. Grosskreutz and M. Turner and S. Vucic and M. Kiernan},
  journal={Clinical Neurophysiology},
  year={2016},
  volume={127},
  pages={2643-2660}
}
  • W. Huynh, N. Simon, +3 authors M. Kiernan
  • Published 2016
  • Medicine
  • Clinical Neurophysiology
  • Clinical signs of upper motor neuron (UMN) involvement are an important component in supporting the diagnosis of amyotrophic lateral sclerosis (ALS), but are often not easily appreciated in a limb that is concurrently affected by muscle wasting and lower motor neuron degeneration, particularly in the early symptomatic stages of ALS. Whilst recent criteria have been proposed to facilitate improved detection of lower motor neuron impairment through electrophysiological features that have improved… CONTINUE READING
    58 Citations
    Upper motor neuron assessment and early diagnosis in ALS
    • 1
    Functional Biomarkers for Amyotrophic Lateral Sclerosis
    • 8
    • PDF
    Primary lateral sclerosis: consensus diagnostic criteria
    • 12
    • PDF
    MRI cortical feature of bulbar impairment in patients with amyotrophic lateral sclerosis
    • 2
    Finding Markers in Amyotrophic Lateral Sclerosis Diagnosis
    The impact of cognitive and behavioral impairment in amyotrophic lateral sclerosis
    • 3
    Neuroimaging Endpoints in Amyotrophic Lateral Sclerosis
    • 38
    • PDF
    Structural and Functional Neuroimaging in Amyotrophic Lateral Sclerosis
    • 2
    • Highly Influenced

    References

    SHOWING 1-10 OF 226 REFERENCES
    Amyotrophic lateral sclerosis: Objective upper motor neuron markers
    • 25
    • Highly Influential
    Neuroimaging as a New Diagnostic Modality in Amyotrophic Lateral Sclerosis
    • 20
    • PDF
    Diagnostic utility of cortical excitability studies in amyotrophic lateral sclerosis
    • 38
    Why are upper motor neuron signs difficult to elicit in amyotrophic lateral sclerosis?
    • M. Swash
    • Medicine
    • Journal of Neurology, Neurosurgery & Psychiatry
    • 2012
    • 75
    • Highly Influential
    Utility of transcranial magnetic stimulation in delineating amyotrophic lateral sclerosis pathophysiology.
    • 23
    Biomarkers in amyotrophic lateral sclerosis
    • 222
    • PDF
    Electrophysiologic evaluation of upper motor neuron involvement in amyotrophic lateral sclerosis
    • V. Drory, I. Kovach, G. B. Groozman
    • Medicine
    • Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
    • 2001
    • 23
    El Escorial revisited: Revised criteria for the diagnosis of amyotrophic lateral sclerosis
    • B. Brooks, R. Miller, M. Swash, T. Munsat
    • Medicine
    • Amyotrophic lateral sclerosis and other motor neuron disorders : official publication of the World Federation of Neurology, Research Group on Motor Neuron Diseases
    • 2000
    • 3,576
    Clinical diagnosis and management of amyotrophic lateral sclerosis
    • 409