Assessment of the septal area neuronal activity during penile erections in rapid eye movement sleep and waking in the rats

  title={Assessment of the septal area neuronal activity during penile erections in rapid eye movement sleep and waking in the rats},
  author={Kamalesh K. Gulia and Yukihiko Kayama and Yoshimasa Koyama},
  journal={The Journal of Physiological Sciences},
To understand the central mechanism of penile erections during rapid eye movement (REM) sleep and waking, single units were recorded from the septal area in un-anesthetized head-restrained rats simultaneous with erections. Erectile events were assessed by pressure in the bulb of the corpus spongiosum of the penis and bulbospongiosus-muscle activity. Of 143 recorded neurons, 36% showed increased activity (E-type) and 24% decreased activity (I-type) during different phases of erection in REM… 

Whole-brain mapping of projection from mouse lateral septal nucleus

The sequence of projections from the lateral septal nucleus by virus tracing is identified and the data on neural circuits, which could help to understand brain function, is expanded.

Narrative review: pathogenesis, diagnosis, and treatment of sleep-related painful erection

Effective support and strategies for doctors to manage SRPE patients are provided through a comprehensive analysis of the pathogenesis mechanism and clinical treatment strategies of SRPE.



Role of the Lateral Preoptic Area in Sleep-Related Erectile Mechanisms and Sleep Generation in the Rat

Lesion analysis revealed that the candidate structures for PS erectile control include both the lateral preoptic area (LPOA) and ventral division of the bed nucleus of the stria terminalis; however, lesions of the LPOA were the most effective in disruptingPS erectile activity.

Electrophysiological, pharmacological and behavioral studies of different physiological roles of the nucleus paragigantocellularis

Findings suggest that the septum plays important role in REM sleep related penile erection in male rats.

Experimental evidence of penile erections during paradoxical sleep in the rat.

It is demonstrated for the first time that rats exhibit penile erections during paradoxical sleep (PS), and this method of chronic penile erection monitoring in the rat provides a new animal model for investigating neural mechanisms of sleep-related erections.

Penile erection and micturition events triggered by electrical stimulation of the mesopontine tegmental area.

The results suggest that the laterodorsal tegmental nucleus (LDT) and surrounding region are involved in the regulation of penile erection and different anatomical areas in the mesopontine tegmentum may have specific roles in theregulation of penILE erection and micturition.

Sleep changes produced by destruction of medial septal neurons in rats

The present findings suggest that the medial septum may be involved in the genesis of slow wave sleep and inhibition of the durations of paradoxical sleep episodes.

PLEASURE AND BRAIN ACTIVITY IN MAN: Deep and Surface Electroencephalograms During Orgasm

  • R. Heath
  • Psychology, Biology
    The Journal of nervous and mental disease
  • 1972
Deep and surface electroencephalograms were recorded during sexual arousal culminating in orgasm in 2 patients, 1 undergoing treatment for severe mental illness and the other for intractable epilepsy, substantiating previously reported data of a consistent correlation between activity in the septal region and the pleasure response.

REM sleep determined using in utero penile tumescence in the human fetus at term.

The finding that there exists a part of the REM period lacking penile tumescence suggests the possible origin of the awake state, brought about by advances in fetal development at this stage of gestation.


There are regularly recurring periods of sleep which are physiologically unique, showing a characteristic EEG pattern together with bursts of bilaterally synchronous, conjugate, rapid vertical and horizontal eye movements, and this physiological pattern is highly correlated with the sleeper's recall of detailed dream experiences.