Assessment of the role of sphingosine 1-phosphate and its receptors in high-density lipoprotein-induced stimulation of astroglial cell function.

@article{Malchinkhuu2003AssessmentOT,
  title={Assessment of the role of sphingosine 1-phosphate and its receptors in high-density lipoprotein-induced stimulation of astroglial cell function.},
  author={Enkhzol Malchinkhuu and Koichi Sato and Takeshi Muraki and Koichi Ishikawa and Atsushi Kuwabara and Fumikazu Okajima},
  journal={The Biochemical journal},
  year={2003},
  volume={370 Pt 3},
  pages={817-27}
}
It has been suggested that lipoproteins in the central nervous system are involved in the regulation of several neural functions independent of cholesterol metabolism as well as those related to lipid metabolism. We recently demonstrated that lipoproteins are carriers for sphingosine 1-phosphate (S1P). This raised the possibility that S1P mediates the neural cell functions induced by lipoproteins. In the current study, we examined the effects of plasma high-density lipoprotein (HDL) on… CONTINUE READING