Assessment of the precorneal residence of an ophthalmic ointment in healthy subjects.

@article{Greaves1993AssessmentOT,
  title={Assessment of the precorneal residence of an ophthalmic ointment in healthy subjects.},
  author={Justine Greaves and Clive G. Wilson and A. T. Birmingham},
  journal={British journal of clinical pharmacology},
  year={1993},
  volume={35 2},
  pages={188-92}
}
1. The precorneal residence of an ophthalmic ointment radiolabelled by inclusion of technetium-99m tin colloid was assessed in seven volunteer subjects using the technique of gamma scintigraphy and compared with a solution of 0.3% w/v hydroxypropylmethylcellulose, (HPMC) radiolabelled by inclusion of technetium-99m diethylenetriaminepentaacetic acid in the same subjects. 2. The mean half-times (+/- s.d.) of corneal residence were 6490 +/- 5404 s (108 min) for the ointment and 13 +/- 24 s for… CONTINUE READING

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