Assessment of the peripheral benzodiazepine receptors in human gliomas by two methods

@article{Miyazawa1998AssessmentOT,
  title={Assessment of the peripheral benzodiazepine receptors in human gliomas by two methods},
  author={Nobuhiko Miyazawa and Edith Hamel and Mirko Diksic},
  journal={Journal of Neuro-Oncology},
  year={1998},
  volume={38},
  pages={19-26}
}
This study was designed to evaluate the density of peripheral benzodiazepine receptor (PBR) sites as a function of tumor malignancy in human gliomas, and to compare the results obtained with autoradiographic and liquid scintillation measurements performed on the same tissue specimens. In vitro binding of [3H]PK-11195[1-(2-chlorophenyl)-N-methyl-(1-methylpropyl)-3-isog uinoline carboxamide] to human gliomas in radioligand binding studies revealed a significantly higher level (about 3 fold) of… CONTINUE READING