Assessment of the pathological stages of Alzheimer's disease in thin paraffin sections: a comparative study.

@article{Nagy1998AssessmentOT,
  title={Assessment of the pathological stages of Alzheimer's disease in thin paraffin sections: a comparative study.},
  author={Zsuzsanna Nagy and Deniz M. Yilmazer-Hanke and Heiko Braak and Eva Braak and Christian Schultz and Jonathan Hanke},
  journal={Dementia and geriatric cognitive disorders},
  year={1998},
  volume={9 3},
  pages={140-4}
}
The staging method proposed by Braak and Braak allows the objective and reliable assessment of Alzheimer-related neurofibrillary pathology. Originally the method was designed for 100-microm thick sections. However, the use of thick sections proved to present difficulties in a routine neuropathology laboratory. In order to adapt the staging method for thin paraffin-embedded sections, we performed an inter- and intrarater study analysing the reliability of the staging method in thin sections… CONTINUE READING