Assessment of the origins and spread of putative resistance-conferring mutations in Plasmodium vivax dihydropteroate synthase.

@article{Hawkins2009AssessmentOT,
  title={Assessment of the origins and spread of putative resistance-conferring mutations in Plasmodium vivax dihydropteroate synthase.},
  author={Vivian N Hawkins and Stephanie M. Suzuki and Kanchana Rungsihirunrat and Hapuarachchige Chanditha Hapuarachchi and Amanda Maestre and Kesara Na-Bangchang and Carol Hopkins Sibley},
  journal={The American journal of tropical medicine and hygiene},
  year={2009},
  volume={81 2},
  pages={348-55}
}
Infection with Plasmodium vivax is usually treated with chloroquine, but parasites are often exposed inadvertently to sulfadoxine-pyrimethamine. To infer patterns of selection and spread of resistant parasites in natural populations, we determined haplotypes of P. vivax dihydropteroate synthase ( dhps ) alleles that could confer resistance to sulfadoxine. We amplified the P. vivax pyrophosphokinase ( pppk )- dhps region and its flanking intergenic regions from 92 contemporary global isolates… CONTINUE READING

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