Assessment of the normal or leukemic nature of CD34+ cells in acute myeloid leukemia with low percentages of CD34 cells.

@article{Pol2003AssessmentOT,
  title={Assessment of the normal or leukemic nature of CD34+ cells in acute myeloid leukemia with low percentages of CD34 cells.},
  author={Marjolein A van der Pol and Nicole Feller and Marjet Roseboom and Bijan Moshaver and Guus A H Westra and Henk J. Broxterman and Gert Jan Ossenkoppele and Gerrit J Schuurhuis},
  journal={Haematologica},
  year={2003},
  volume={88 9},
  pages={983-93}
}
BACKGROUND AND OBJECTIVES The percentages of CD34+ cells in the bone marrow of patients with acute myeloid leukemia (AML) vary widely. Especially in the low range (<5% CD34+ cells), the nature (normal or malignant) of the CD34+ cells is uncertain. Since only in a minority of cases are molecular techniques applicable, in this study we explored a multiparameter approach using phenotypic and functional characteristics to discriminate normal CD34+ cells from malignant ones. DESIGN AND METHODS… CONTINUE READING