Assessment of the mass balance recovery and metabolite profile of avibactam in humans and in vitro drug-drug interaction potential.

@article{Vishwanathan2014AssessmentOT,
  title={Assessment of the mass balance recovery and metabolite profile of avibactam in humans and in vitro drug-drug interaction potential.},
  author={Karthick Vishwanathan and Stuart J Mair and Anshul Gupta and James G Atherton and Jacqueline A Clarkson-Jones and Timi Edeki and Shampa Das},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2014},
  volume={42 5},
  pages={932-42}
}
Avibactam, a novel non-β-lactam β-lactamase inhibitor with activity against Ambler class A, class C, and some class D enzymes is being evaluated in combination with various β-lactam antibiotics to treat serious bacterial infections. The in vivo mass balance recovery and metabolite profile of [(14)C] avibactam (500 mg/1-h infusion) was assessed in six healthy male subjects, and a series of in vitro experiments evaluated the metabolism and drug-drug interaction potential of avibactam. In the mass… CONTINUE READING
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