Assessment of the influence factors on in vitro testing of nasal sprays using Box-Behnken experimental design.

@article{Guo2008AssessmentOT,
  title={Assessment of the influence factors on in vitro testing of nasal sprays using Box-Behnken experimental design.},
  author={Changning Guo and Keith J. Stine and John F Kauffman and William Hill Doub},
  journal={European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences},
  year={2008},
  volume={35 5},
  pages={417-26}
}
The purpose of the research was to investigate the influences of actuation parameters and formulation physical properties on nasal spray delivery performance using design of experiment (DOE) methodology. A 3-level, 4-factor Box-Behnken design with a total of 27 experimental runs was used in this study. Nine simulated aqueous formulations with different viscosities and surface tensions were prepared using carboxymethylcellulose sodium (CMC, gelling agent) and Tween80 (surfactant) each at three… CONTINUE READING

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