Assessment of the hypothalamo-pituitary-adrenal axis in patients treated with radiotherapy and chemotherapy for childhood brain tumor.

@article{Schmiegelow2003AssessmentOT,
  title={Assessment of the hypothalamo-pituitary-adrenal axis in patients treated with radiotherapy and chemotherapy for childhood brain tumor.},
  author={Marianne Schmiegelow and Ulla Feldt-Rasmussen and Aase Krogh Rasmussen and Martin Lange and Hans Skovgaard Poulsen and J\orn M{\"u}ller},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2003},
  volume={88 7},
  pages={3149-54}
}
The impact of cranial irradiation (CIR) and chemotherapy on the hypothalamo-pituitary (HP)-adrenal (HPA) axis was assessed in a population-based follow-up study of patients treated for childhood brain tumor not directly involving the HP axis. HPA function was evaluated and compared with that in healthy controls (n = 17), measuring basal cortisol and the peak cortisol response to an insulin tolerance test (ITT) and an ACTH test(.) The cortisol cut-off level was 500 nmol/liter. The biological… CONTINUE READING