Assessment of the effect of mefloquine on artesunate pharmacokinetics in healthy male volunteers.

@article{Davis2007AssessmentOT,
  title={Assessment of the effect of mefloquine on artesunate pharmacokinetics in healthy male volunteers.},
  author={Timothy M E Davis and Michelle England and A Dunlop and Madhu Page-Sharp and Nathalie Cambon and Thomas G Keller and J{\'a}nos L. Heidecker and Kenneth F. Ilett},
  journal={Antimicrobial agents and chemotherapy},
  year={2007},
  volume={51 3},
  pages={1099-101}
}
The effect of mefloquine on artesunate pharmacokinetics was assessed in 20 volunteers given artesunate for 3 days, followed > or =21 days later by combination therapy for 3 days. The areas under the concentration-time curve from 0 h to infinity for dihydroartemisinin, the active metabolite of artesunate, were similar on day 3 of the two dosing periods (P = 0.12), implying no interaction.