Assessment of the effect of glucosamine sulfate and exercise on knee cartilage using magnetic resonance imaging in patients with knee osteoarthritis: a randomized controlled clinical trial.

@article{Durmu2012AssessmentOT,
  title={Assessment of the effect of glucosamine sulfate and exercise on knee cartilage using magnetic resonance imaging in patients with knee osteoarthritis: a randomized controlled clinical trial.},
  author={Dilek Durmuş and Gamze Alaylı and İlkay Koray Bayrak and Ferhan Canturk},
  journal={Journal of back and musculoskeletal rehabilitation},
  year={2012},
  volume={25 4},
  pages={
          275-84
        }
}
INTRODUCTION Osteoarthritis (OA) is a chronic disease characterized by the focal deterioration and abrasion of articular cartilage. The goals of therapy are preserving normal joint function, relieving pain and improving quality of life (QOL). This study is performed to investigate whether glocosamine sulfate and exercise could both delay joint structure degradation evaluated with magnetic resonance imaging (MRI) and improve symptoms in a short time period. MATERIALS AND METHODS Thirty-nine… 

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References

SHOWING 1-10 OF 64 REFERENCES

Positive effects of moderate exercise on glycosaminoglycan content in knee cartilage: a four-month, randomized, controlled trial in patients at risk of osteoarthritis.

This in vivo cartilage monitoring study in patients at risk of knee OA who begin exercising indicates that adult human articular cartilage has a potential to adapt to loading change.

Glucosamine sulfate use and delay of progression of knee osteoarthritis: a 3-year, randomized, placebo-controlled, double-blind study.

Long-term treatment with glucosamine sulfate retarded the progression of knee osteoarthritis, possibly determining disease modification.

Glucosamine sulfate in the treatment of knee osteoarthritis symptoms: a randomized, double-blind, placebo-controlled study using acetaminophen as a side comparator.

The findings of this study indicate that glucosamine sulfate at the oral once-daily dosage of 1,500 mg is more effective than placebo in treating knee OA symptoms.

Quadriceps strength and the risk of cartilage loss and symptom progression in knee osteoarthritis.

It is reported for the first time that greater quadriceps strength protected against cartilage loss at the lateral compartment of the patellofemoral joint, a finding that requires confirmation.

Effect of Glucosamine Sulfate on Hip Osteoarthritis

A 2-year, blinded, randomized, placebo-controlled trial to evaluate the effect of glucosamine sulfate on the symptomatic and radiographic progression of hip osteoarthritis in patients recruited from primary care settings.

Current role of glucosamine in the treatment of osteoarthritis.

Symptomatic efficacy described in multiple studies performed with glucosamine sulphate (GS) support continued consideration in the OA therapeutic armamentarium and the most compelling evidence of a potential for inhibiting the progression of OA is also obtain with GS.

Weight loss in obese people has structure-modifying effects on medial but not on lateral knee articular cartilage

Weight loss is associated with improvements in the quality (increased proteoglycan content) and quantity (reduced cartilage thickness losses) of medial articular cartilage, which could ultimately lead to a reduced need for total joint replacements.

Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial

Exercise caused an increase in both intraarticular and peri-synovial concentrations of IL-10 in a group of human females with knee OA, suggesting a positive effect of exercise on a chondroprotective anti-inflammatory cytokine response in patients with kneeOA.
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