Assessment of the chemotherapeutic potential of a new camptothecin derivative, ZBH-1205.

@article{Wu2016AssessmentOT,
  title={Assessment of the chemotherapeutic potential of a new camptothecin derivative, ZBH-1205.},
  author={Di Wu and Weiguo Shi and Jing Zhao and Zhengren Wei and Zhijiao Chen and Dawei Zhao and Shijie Lan and Jiandong Tai and Bohua Zhong and Hong Yu},
  journal={Archives of biochemistry and biophysics},
  year={2016},
  volume={604},
  pages={
          74-85
        }
}
CPT-11 (irinotecan) is a derivative of camptothecin which is a natural product derived from the Chinese tree Camptotheca acuminta and widely used in antitumor therapy. Here, the in vitro anti-tumor activity and associated mechanisms of a novel derivative of camptothecin, ZBH-1205, were investigated in a panel of 9 human tumor cell lines, as well as in HEK 293 and SK-OV-3/DPP, a multi-drug resistant (MDR) cell line, and compared to CPT-11 and 7-ethyl-10-hydroxy-camptothecin (SN38). Comparisons… Expand
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