Assessment of the abuse potential of methamnetamine in rodents: a behavioral pharmacology study.

  title={Assessment of the abuse potential of methamnetamine in rodents: a behavioral pharmacology study.},
  author={Dong-Hyun Youn and Jin Mook Kim and Young-ki Hong and Seo-in Park and Jin-Moo Lee and Young-Hoon Kim and Chang Won Park and Mi Sun Kang},
RATIONALE Methamnetamine (MNA; PAL-1046) is a new psychoactive substance that acts as a full biogenic amine transporter (BAT) substrate. BAT substrates promote neurotransmitter release from the nerve terminal and can be abused as stimulants. However, scientific information on the abuse potential of methamnetamine is lacking. OBJECTIVE We evaluated the abuse liability of methamnetamine. METHODS The effective dose range of methamnetamine was determined using a climbing behavior test. The… 


Agents in Development for the Management of Cocaine Abuse
Four medications warranting phase II controlled clinical trials: cabergoline, reserpine, sertraline and tiagabine, and two dopamine receptor ligands that reduce cocaine self-administration in animals are also undergoing phase I human safety trials.
Dopamine in drug abuse and addiction: results from imaging studies and treatment implications
It is postulate that decreased dopamine function in addicted subjects results in decreased sensitivity to nondrug-related stimuli (including natural reinforcers) and disrupts frontal inhibition, both of which contribute to compulsive drug intake and impaired inhibitory control.
Novel psychoactive substances of interest for psychiatry
Novel psychoactive substances include synthetic cannabinoids, cathinone derivatives, psychedelic phenethylamines, novel stimulants, synthetic opioids, tryptamine derivatives, phencyclidine‐like
Amphetamine induces dopamine efflux through a dopamine transporter channel.
It is reported that AMPH causes DAT-mediated DA efflux by two independent mechanisms: a slow process consistent with an exchange mechanism and a process that results in rapid (millisecond) bursts ofDA efflux through a channel-like mode of DAT.