Assessment of the Topical and Systemic Effects of Omega-3 on Oral mucosal wound healing in albino rats: A Histopathological and Biochemical study

  title={Assessment of the Topical and Systemic Effects of Omega-3 on Oral mucosal wound healing in albino rats: A Histopathological and Biochemical study},
  author={Soha Basha and Sahar Mahmoud ElRefai and Mervet M. Moussa},
The use of herbal medicine is increasingly becoming more accepted in treatment of many inflammatory conditions. Omega-3 is recently introduced as an effective therapeutic agent and a powerful anti-inflammatory agent, which promotes whole-body wound healing including ulcers as it has an important role in modulation of proinflammatory cytokine production. This study was conductedto evaluate and compare the effect of topicalapplication and systemic administration of omega-3 on the healing of oral… 

Figures and Tables from this paper

Formulasi Emulgel Minyak Ikan Salmon dengan Gelling Agent Na-Alginat dari Alga Coklat (Sargassum sp)
Penelitian ini bertujuan untuk mengetahui kemampuan Na-alginat yang berasal dari Sargassum sp sebagai gelling agent dalam sediaan emulgel minyak ikan salmon. Pembuatan formula emulgel minyak ikan


Effects of Locally and Systemically Applied n-3 Fatty Acid on Oral Ulcer Recovery Process in Rats.
Omega-3 fatty acid (L and S) increases fibroblast counts and decreases PMN cell counts and this compound causes an increase in reepithelialization and epithelial thickness.
Effects of parenteral fish-oil emulsion (Omegaven) on cutaneous wound healing in rats treated with dexamethasone.
Adding parenteral omega-3 and omega-6 fatty acids to the nutrition regimen of rats treated with dexamethasone does not seem to have adverse effects on wound healing, and effects on wounds healing may not need to be considered when determining if these agents should be supplemented in nutrition support regimens.
Preoperative supplementation of omega-3 fatty acid in rats is associated with increased collagen deposition of type I fibers in colonic anastomoses on the 5th postoperative day, and no differences were observed in the tensile strength or collagen maturation index.
Curcumin as a wound healing agent.
Topical application of cod liver oil ointment accelerates wound healing: an experimental study in wounds in the ears of hairless mice.
Topical 25% cod liver oil ointment significantly accelerated both the epithelial and the vascular component of healing compared with saline and vitamin A seems to have an important role in accelerating wound healing and could be the active component in cod liverOil.
Influence of topical administration of n‐3 and n‐6 essential and n‐9 nonessential fatty acids on the healing of cutaneous wounds
Evidence is presented that linolenic, linoleic, and oleic fatty acids can modulate the closure of surgically induced skin wounds and a relevant role and potential therapeutic implication for fatty acids on skin wound healing are suggested.
Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection.
This combination of arginine and omega-3 polyunsaturated fatty acids in fish oil has been shown to affect outcomes involving wound healing and infections, and can also affect incidence and outcomes in cardiovascular disease, diabetes, organ transplant rejection, and other inflammatory conditions.
Dietary supplementation with omega-3 fatty acid attenuates 5-fluorouracil induced mucositis in mice
It is shown that omega-3 fatty acid decreases the mucosal damage caused by 5-FU-induced mucositis and is also associated with mucosal integrity and a reduced number of apoptotic cells in the ileum mucosa compared to the mice that received the control diet and5-FU injection.
Omega-3 fatty acids enhance ligament fibroblast collagen formation in association with changes in interleukin-6 production.
It is demonstrated that n-3 PUFA (represented by EPA in this study) positively affect the healing characteristics of MCL cells and therefore may represent a possible noninvasive treatment to improve ligament healing.
Effect of fish oil on offensive and defensive factors in gastric ulceration in rats.