Assessment of the Role of Renal Organic Anion Transporters in Drug-Induced Nephrotoxicity

@inproceedings{Hagos2010AssessmentOT,
  title={Assessment of the Role of Renal Organic Anion Transporters in Drug-Induced Nephrotoxicity},
  author={Yohannes Hagos and Natascha A. Wolff},
  booktitle={Toxins},
  year={2010}
}
In the present review we have attempted to assess the involvement of the organic anion transporters OAT1, OAT2, OAT3, and OAT4, belonging to the SLC22 family of polyspecific carriers, in drug-induced renal damage in humans. We have focused on drugs with widely recognized nephrotoxic potential, which have previously been reported to interact with OAT family members, and whose underlying pathogenic mechanism suggests the participation of tubular transport. Thus, only compounds generally believed… CONTINUE READING

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