Assessment of the Role of NO-cGMP Pathway in Orthodontic Tooth Movement Using PDE5 Inhibitors: An Animal Study

Abstract

OBJECTIVES Nitric oxide (NO) is a signaling molecule that mediates mechanical bone loading. Cyclic guanosine 3', 5' monophosphate (cGMP) is a NO-induced effector molecule. The aim of this study was to assess the effect of NO-cGMP pathway on orthodontic tooth movement (OTM) in rats by use of two phosphodiesterase 5 (PDE5) inhibitors namely sildenafil and… (More)

Topics

2 Figures and Tables

Cite this paper

@inproceedings{Mirhashemi2016AssessmentOT, title={Assessment of the Role of NO-cGMP Pathway in Orthodontic Tooth Movement Using PDE5 Inhibitors: An Animal Study}, author={Amir Hossein Mirhashemi and Mohammad Sadegh Ahmad Akhoundi and Rezvaneh Ghazanfari and Shahroo Etemad-Moghadam and Mojgan Alaeddini and Azam Khorshidian and Ahmad R Dehpour and Nafiseh Momeni}, booktitle={Journal of dentistry}, year={2016} }