Assessment of the Pulmonary Genotoxicity of Bitumen Fumes in Big Blue® Transgenic Rats

@inproceedings{Gat2007AssessmentOT,
  title={Assessment of the Pulmonary Genotoxicity of Bitumen Fumes in Big Blue® Transgenic Rats},
  author={Laurent Gat{\'e} and Marie Claire Bottin and Bertrand Henri Rihn and Jean Claude Micillino and Nathalie Monhoven and Herv{\'e} Nunge and Georges Morel and Richard Wrobel and Catherine Champmartin and G. Keith and St{\'e}phane Binet},
  year={2007}
}
Occupational and environmental exposures to bitumen fumes during road paving or roofing activities represent a safety issue since this complex mixture of volatile compounds and particles contains carcinogenic polycyclic aromatic hydrocarbons (PAH). However, epidemiological and experimental animal studies failed to draw unambiguous conclusions concerning bitumen fumes toxicity. In order to gain better insights on their genotoxic potential, we used an experimental device able to generate bitumen… CONTINUE READING