Assessment of the N-oxidation of deprenyl, methamphetamine, and amphetamine enantiomers by chiral capillary electrophoresis: an in vitro metabolism study.

@article{Szk2004AssessmentOT,
  title={Assessment of the N-oxidation of deprenyl, methamphetamine, and amphetamine enantiomers by chiral capillary electrophoresis: an in vitro metabolism study.},
  author={{\'E}va Sz{\"o}kő and Tam{\'a}s T{\'a}bi and T{\'i}mea Borb{\'a}s and Bal{\'a}zs Dalmadi and K{\'a}roly Tihanyi and K{\'a}lm{\'a}n Magyar},
  journal={Electrophoresis},
  year={2004},
  volume={25 16},
  pages={2866-75}
}
A chiral capillary electrophoresis method using hydroxypropyl-beta-cyclodextrin as chiral selector was developed and validated for the quantification of the N-oxygenated metabolites of deprenyl, methamphetamine, and amphetamine enantiomers, formed in vitro. The influence of various parameters (selector concentration, buffer pH, temperature, polymer additive, etc.) on the simultaneous separation of the optical isomers of the parent drugs and their metabolites has been evaluated. The buffer pH… CONTINUE READING

Similar Papers

Loading similar papers…