Assessment of the Effect of Sorafenib on Omega-6 and Omega-3 Epoxyeicosanoid Formation in Patients with Hepatocellular Carcinoma

  title={Assessment of the Effect of Sorafenib on Omega-6 and Omega-3 Epoxyeicosanoid Formation in Patients with Hepatocellular Carcinoma},
  author={Can G Leineweber and Anne Pietzner and Ingrid W Zhang and U. Blessin and M. Rothe and E. Schott and N. H. Schebb and K. Weylandt},
  journal={International Journal of Molecular Sciences},
  • Can G Leineweber, Anne Pietzner, +5 authors K. Weylandt
  • Published 2020
  • Medicine
  • International Journal of Molecular Sciences
  • Hepatocellular carcinoma (HCC) is a leading cause of cancer death. The multikinase inhibitor sorafenib is widely used for systemic therapy in advanced HCC. Sorafenib might affect epoxyeicosanoids, as it is also a potent inhibitor of the soluble epoxide hydrolase (sEH), which catalyzes the conversion of epoxides derived from long-chain polyunsaturated fatty acids (PUFAs), such as arachidonic acid (AA) and omega-3 docosahexaenoic acid (DHA), into their corresponding diols. Experimental studies… CONTINUE READING
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