Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine

  title={Assessment of the Airway Smooth Muscle Relaxant Effect of Drotaverine},
  author={Zolt{\'a}n Patai and Andr{\'a}s Guttman and Endre G. Mikus},
  pages={163 - 169}
Background: Drotaverine, a type 4 cyclic nucleotide phosphodiesterase (PDE4) inhibitor, blocks the degradation of 3’,5’-cyclic adenosine monophosphate. However, published receptor binding data showed that drotaverin also binds to the L-type voltage-operated calcium channel (L-VOCC). Based on these molecular mechanisms of action, a direct and indirect (by blocking the constrictor response) relaxant effect on airway smooth muscle can be predicted, which has not yet been assessed. Summary… Expand


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