Assessment of the Abuse Potential of the Orexin Receptor Antagonist, Suvorexant, Compared With Zolpidem in a Randomized Crossover Study

  title={Assessment of the Abuse Potential of the Orexin Receptor Antagonist, Suvorexant, Compared With Zolpidem in a Randomized Crossover Study},
  author={Kerri A. Schoedel and Hong Sun and Edward Sellers and Janice Faulknor and N. Levy-Cooperman and Xiaodong Li and William P. Kennedy and Jang-Ho Cha and Nicole Lewis and Wen Liu and Phung Bondiskey and Jacqueline B McCrea and Deborah L. Panebianco and Matthew D. Troyer and John A. Wagner},
  journal={Journal of Clinical Psychopharmacology},
Abstract Suvorexant is a dual orexin receptor antagonist approved in the United States and Japan for the treatment of insomnia at a maximum dose of 20 mg. This randomized double-blind crossover study evaluated the abuse potential of suvorexant in 36 healthy recreational polydrug users with a history of sedative and psychedelic drug use. Single doses of suvorexant (40, 80, and 150 mg: 2–7.5 × maximum dose), zolpidem (15 and 30 mg: 1.5–3 × maximum dose), and placebo were administered, with a 10… 

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