Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: a guide for clinical, translational, and basic researchers.
@article{Burkhoff2005AssessmentOS,
title={Assessment of systolic and diastolic ventricular properties via pressure-volume analysis: a guide for clinical, translational, and basic researchers.},
author={Daniel Burkhoff and I. Arthur Mirsky and Hiroyuki Suga},
journal={American journal of physiology. Heart and circulatory physiology},
year={2005},
volume={289 2},
pages={
H501-12
}
}Assessment of left ventricular systolic and diastolic pump properties is fundamental to advancing the understanding of cardiovascular pathophysiology and therapeutics, especially for heart failure. The use of end-systolic and end-diastolic pressure-volume relationships derived from measurements of instantaneous left ventricular pressure-volume loops emerged in the 1970s as a comprehensive approach for this purpose. As invasive and noninvasive techniques for measuring ventricular volume improved…
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References
SHOWING 1-10 OF 103 REFERENCES
From 'Emax' to pressure-volume relations: a broader view.
- MedicineCirculation
- 1988
THE REQUIREMENT for making accurate and detailed assessments of organ function has always depended on the scope and capabilities of available therapies. Over the past decade, we have witnessed an…
The development of the entire end-systolic pressure-volume and ejection fraction-afterload relations: a new concept of systolic myocardial stiffness.
- BiologyCirculation
- 1987
Vom and max Eav permit development of the entire ejection fraction-afterload relationship for a given preload, thus providing a method for comparing myocardial contractile states between ventricles and normalization of Emax with Vom demonstrated a close relationship tomax Eav.
Evaluation of Left Ventricular Contractile Performance Utilizing End‐Systolic Pressure‐Volume Relationships in Conscious Dogs
- Medicine, BiologyCirculation research
- 1984
It is concluded that linear end-systolic pressure-volume relationships can be derived in conscious dogs with intact sympathetic reflexes, and appears to reflect left ventricular contractile function and is indepednent of the level of afterload and preload.
Noninvasive single-beat determination of left ventricular end-systolic elastance in humans.
- Medicine, EngineeringJournal of the American College of Cardiology
- 2001
Left ventricular pressure-volume diagrams and end-systolic pressure-volume relations in human beings.
- MedicineJournal of the American College of Cardiology
- 1984
Evidence and quantitation of left ventricular systolic resistance.
- BiologyThe American journal of physiology
- 1985
The unique isovolumetric pressure-resistance relation suggests that the rate-limiting properties of the contractile process may be causally related to the observed ventricular resistive behavior.
Simultaneous determination of left ventricular end-systolic pressure-volume and pressure-dimension relationships in closed-chest dogs.
- Medicine, BiologyCirculation
- 1985
The left ventricular end-systolic pressure-volume relationship is a load-insensitive measure ofLeft ventricular performance and the conflicting results of previous studies make it unclear if the pressure--anterior-posterior dimension and pressure--septal-lateral dimension relationships were relatively unaffected.
Lack of relationship between Doppler indices of diastolic function and left ventricular pressure transients in patients with definite diastolic heart failure.
- MedicineAmerican heart journal
- 2004
Ventricular systolic assessment in patients with dilated cardiomyopathy by preload-adjusted maximal power. Validation and noninvasive application.
- MedicineCirculation
- 1994
Preload-adjusted PWRmx is a steady-state index of ventricular systolic function that is sensitive to inotropic state and minimally influenced by physiological changes in afterload impedance or volume load, and appears useful for noninvasive cardiac-specific analysis of acute drug effects.
Nonlinearity and load sensitivity of end-systolic pressure-volume relation of canine left ventricle in vivo.
- BiologyCirculation
- 1991
The results indicate that the ESPVR and dP/dtmax-Ved and stroke work-end-diastolic volume relations, when studied over a wide volume range, are nonlinear and that changes in loading conditions influence indexes of contractility derived from these relations, especially the volume intercepts, in such a way that an increase in aortic impedance may be interpreted as a increase in contractility.









