Assessment of serum thyroxine binding capacity-dependent biases in free thyroxine assays.

@article{Christofides1999AssessmentOS,
  title={Assessment of serum thyroxine binding capacity-dependent biases in free thyroxine assays.},
  author={Nicholas D Christofides and Ewan Wilkinson and Mary Stoddart and David Charles Ray and Geoff J. Beckett},
  journal={Clinical chemistry},
  year={1999},
  volume={45 4},
  pages={520-5}
}
BACKGROUND Free thyroxine (FT4) assays may exhibit biases that are related to serum T4 binding capacity (sBC). We describe two tests that can be used to assess the presence and magnitude of sBC-dependent biases in FT4 assays. METHODS We used a direct equilibrium dialysis FT4 assay as the reference method and compared the results obtained with those of the FT4 assays under investigation, in patient sera having a wide range of sBC. We then compared the expected and observed FT4 results for sera… CONTINUE READING

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