Assessment of prognostic circulating tumor cells in a phase III trial of adjuvant immunotherapy after complete resection of stage IV melanoma.

@article{Hoshimoto2012AssessmentOP,
  title={Assessment of prognostic circulating tumor cells in a phase III trial of adjuvant immunotherapy after complete resection of stage IV melanoma.},
  author={Sojun Hoshimoto and Mark B Faries and DonaldL. Morton and Tatsushi Shingai and Christine Kuo and He-jing Wang and Robert M. Elashoff and Nicola Mozzillo and Mark C. Kelley and John F Thompson and Jeffrey E. Lee and Dave S. B. Hoon},
  journal={Annals of surgery},
  year={2012},
  volume={255 2},
  pages={
          357-62
        }
}
OBJECTIVE To verify circulating tumor cell (CTC) prognostic utility in stage IV resected melanoma patients in a prospective international phase III clinical trial. BACKGROUND Our studies of melanoma patients in phase II clinical trials demonstrated prognostic significance for CTCs in patients with AJCC stage IV melanoma. CTCs were assessed to determine prognostic utility in follow-up of disease-free stage IV patients pre- and during treatment. METHODS After complete metastasectomy, patients… CONTINUE READING
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