Assessment of prognosis in acute liver failure.

  title={Assessment of prognosis in acute liver failure.},
  author={J. Polson},
  journal={Seminars in liver disease},
  volume={28 2},
  • J. Polson
  • Published 2008
  • Medicine
  • Seminars in liver disease
Determining prognosis in acute liver failure (ALF) is vital to consideration of transplantation for these critically ill patients. Transplanting a likely survivor may be as unfortunate as not transplanting someone whose outcome is very poor. Prognostic scoring systems have largely failed to accurately portray outcomes, partly because the use of transplantation does not allow the true transplant-free outcome to unfold. The King's College Hospital criteria have not proved accurate enough in… Expand
Liver transplantation in acute liver failure: A challenging scenario.
In this challenging scenario, where organ shortage remains one of the main problems, alternatives to conventional orthotopic liver transplantation, such as living-donor liver transplation, auxiliary liver transplant, and ABO-incompatible grafts should be explored. Expand
Development of an accurate index for predicting outcomes of patients with acute liver failure.
The ALFSG index, a combination of clinical markers and measurements of the apoptosis biomarker M30, better predicts outcomes of patients with ALF than the KCC or MELD. Expand
Management of acute liver failure
Advances in the intensive care management of patients with ALF are highlighted that have contributed to a marked improvement in their overall survival over the past 20 years, including therapies that limit the extent of liver injury and maximize the likelihood of spontaneous recovery. Expand
Critical management decisions in patients with acute liver failure.
Recent advances in the assignment of an etiology, the administration of etiology-specific treatment to abate the liver injury, and the management of complications in patients with ALF are considered. Expand
[Acute liver failure in Korea: etiology, prognosis and treatment].
  • Y. Lim
  • Medicine
  • The Korean journal of hepatology
  • 2010
As the window during which transplantation is possible is limited, emergency adult LDLT should be considered to be one of the first-line treatment options in patients with ALF, especially in regions in which ALFs are caused by etiologies associated with poor outcome and the supply of organs is very limited. Expand
Predicting the prognosis in acute liver failure: results from a retrospective pilot study using the LiMAx test.
Maximal liver function capacity determined by LiMAx test is severely impaired in patients with ALF and the LiMAX test might be effective in predicting the individual prognosis and the need for LTX in ALF. Expand
Liver maximum capacity (LiMAx) test as a helpful prognostic tool in acute liver failure with sepsis: a case report
Improvement of enzymatic liver function measured by the LiMAx test was the first parameter predicting beneficial outcome in a patient with ALF complicated by sepsis, reports a formerly healthy 20-year old male caucasian patient. Expand
Outcome of acute liver failure in the elderly
In contrast to previous studies, this work has demonstrated a relatively good spontaneous survival rate for older patients with ALF when it is corrected for etiology, and overall survival was better for younger non‐acetaminophen patients. Expand
Serum sodium based modification of the MELD does not improve prediction of outcome in acute liver failure
This study validated the prognostic value of MELD-Na and UKELD in ALF and found that the classical MELD score was superior to sodium-based modifications and KCC in the prediction of NSR. Expand
Evaluation of the liver injury unit scoring system to predict survival in a multinational study of pediatric acute liver failure.
Based on data from a large, multicenter cohort of patients with PALF, the LIU score was a better predictor of transplant-free survival than was the aLIU score. Expand