Assessment of pre-diagnosis biomarkers of immune activation and inflammation: insights on the etiology of lymphoma.


The DNA-modifying processes that are involved in B lymphocyte activation, somatic hypermutation (SHM), and IgH class switch recombination (CSR) have the potential to lead to genetic errors that lead to the genesis of B cell cancers, such as lymphoma. Given the potential contribution of these immune mechanisms to the development of cancer, assessment of the… (More)
DOI: 10.1021/pr100729z